Nexø E, Poulsen S S
Scand J Gastroenterol Suppl. 1987;127:45-9. doi: 10.3109/00365528709090950.
Epidermal growth factor (EGF) is a mitogenic peptide synthesized in the submandibular glands and released in saliva. EGF is able to prevent the development of gastrointestinal ulcers in the rat and to accelerate their healing. The present work was undertaken to examine whether Sucralfate acts via the effector system of EGF. We conclude that Sucralfate does not change the binding of EGF to its receptor, but it is able to bind EGF in a pH dependent manner and at pH below 4.5 virtually all EGF is bound to Sucralfate. In vivo studies in rats with acid-induced gastric ulcers show that sucralfate carries EGF to the ulcer, and that EGF is available for a longer period of time (3 hours) when EGF and Sucralfate are is given together than when EGF is given alone.
表皮生长因子（EGF）是一种在下颌下腺合成并随唾液释放的促有丝分裂肽。EGF能够预防大鼠胃肠道溃疡的发生并加速其愈合。本研究旨在探讨硫糖铝是否通过EGF的效应系统发挥作用。我们得出结论，硫糖铝不会改变EGF与其受体的结合，但它能够以pH依赖的方式结合EGF，在pH低于4.5时，几乎所有的EGF都与硫糖铝结合。对酸诱导的大鼠胃溃疡进行的体内研究表明，硫糖铝将EGF携带至溃疡部位，并且当EGF与硫糖铝一起给药时，EGF在较长时间内（3小时）都可利用，而单独给予EGF时则不然。
