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表皮生长因子在消化性溃疡愈合中的作用。

Role of epidermal growth factor in peptic ulcer healing.

作者信息

Calabrò A, Milani S, Paladini I, Orsini B, Salvadori G, Surrenti C

机构信息

Department of Clinical Pathophysiology, University of Florence, Italy.

出版信息

Dig Dis Sci. 1995 Nov;40(11):2497-504. doi: 10.1007/BF02063264.

DOI:10.1007/BF02063264
PMID:7587841
Abstract

In recent years, increasing interest has been focused on peptide growth factors, and impressive progress has been made in the understanding of their role in tumor development and progression. However, evidence is mounting that peptides such as epidermal growth factor and transforming growth factor-alpha may be of much more physiological than pathological importance. This brief article is intended to give a rapid overview of the available data supporting a role for epidermal growth factor and its human homologue urogastrone in peptic ulcer healing.

摘要

近年来,人们对肽生长因子的兴趣日益浓厚,在理解它们在肿瘤发生和发展中的作用方面取得了令人瞩目的进展。然而,越来越多的证据表明,诸如表皮生长因子和转化生长因子-α等肽可能在生理方面比病理方面更为重要。这篇短文旨在快速概述支持表皮生长因子及其人类同源物尿抑胃素在消化性溃疡愈合中发挥作用的现有数据。

相似文献

1
Role of epidermal growth factor in peptic ulcer healing.表皮生长因子在消化性溃疡愈合中的作用。
Dig Dis Sci. 1995 Nov;40(11):2497-504. doi: 10.1007/BF02063264.
2
Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa.表皮生长因子在胃十二指肠黏膜保护、修复及愈合中的作用
J Clin Gastroenterol. 1991;13 Suppl 1:S88-97. doi: 10.1097/00004836-199112001-00015.
3
[Urogastrone excretion in peptic ulcer in healthy persons with a varying intensity of hydrochloric acid secretion in the stomach].[胃内盐酸分泌强度各异的健康人消化性溃疡中尿抑胃素的排泄情况]
Ter Arkh. 1978;50(10):20-2.
4
Epidermal growth factor in the gastroprotective and ulcer-healing actions of sucralfate in rats.表皮生长因子在大鼠中硫糖铝的胃保护和溃疡愈合作用中的作用。
Am J Med. 1989 Jun 9;86(6A):32-7. doi: 10.1016/0002-9343(89)90154-x.
5
Interaction of growth hormone-releasing factor and somatostatin on ulcer healing and mucosal growth in rats: role of gastrin and epidermal growth factor.生长激素释放因子与生长抑素对大鼠溃疡愈合及黏膜生长的相互作用:胃泌素和表皮生长因子的作用
Digestion. 1988;41(3):121-8. doi: 10.1159/000199763.
6
Growth factors and wound healing in otolaryngology.
Otolaryngol Head Neck Surg. 1994 Jun;110(6):560-4. doi: 10.1177/019459989411000615.
7
Enterogastrone, anthelone and urogastrone; a review of the literature and a suggestion for the organization of a national committee for the study of peptic ulcer.肠抑胃素、抗溃疡素与尿抑胃素;文献综述及关于组建全国消化性溃疡研究委员会的建议
Gastroenterology. 1945 Nov;5:404-15.
8
Epithelial-mesenchymal interaction in gastric mucosal restoration.胃黏膜修复中的上皮-间质相互作用
J Gastroenterol. 2000;35 Suppl 12:65-8.
9
Peptide growth factors and wound healing.肽生长因子与伤口愈合。
Clin Plast Surg. 1990 Jul;17(3):421-32.
10
[Influence of smoking on the effectiveness of peptic ulcer healing].[吸烟对消化性溃疡愈合效果的影响]
Wiad Lek. 2014;67(2 Pt 2):273-5.

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Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets.用于慢性萎缩性胃炎的中药:疗效、作用机制及靶点
World J Gastroenterol. 2025 Mar 7;31(9):102053. doi: 10.3748/wjg.v31.i9.102053.
2
Interleukin-1beta inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers.白细胞介素-1β抑制生长因子刺激的大鼠胃上皮细胞单层损伤修复。
Dig Dis Sci. 1998 Mar;43(3):476-84. doi: 10.1023/a:1018890419648.
3
Expression of epidermal growth factor, transforming growth factor-alpha and their receptor in the human oesophagus.

本文引用的文献

1
Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.从小鼠颌下腺中分离出一种可加速新生动物门齿萌出和睁眼的蛋白质。
J Biol Chem. 1962 May;237:1555-62.
2
Localization of epidermal growth factor/transforming growth factor-alpha receptor in the human gastric mucosa. An immunohistochemical and in situ hybridization study.人胃黏膜中表皮生长因子/转化生长因子-α受体的定位。一项免疫组织化学和原位杂交研究。
Virchows Arch A Pathol Anat Histopathol. 1993;423(1):57-63. doi: 10.1007/BF01606433.
3
Influence of epidermal growth factor on the development of suckling mouse intestinal mucosa.
表皮生长因子、转化生长因子-α及其受体在人食管中的表达
Histochem J. 1997 Oct;29(10):745-58. doi: 10.1023/a:1026469219190.
表皮生长因子对哺乳小鼠肠黏膜发育的影响
Gastroenterology. 1982 Jul;83(1 Pt 1):28-35.
4
Circadian phase-dependent stimulatory effects of epidermal growth factor on deoxyribonucleic acid synthesis in the duodenum, jejunum, ileum, caecum, colon, and rectum of the adult male mouse.表皮生长因子对成年雄性小鼠十二指肠、空肠、回肠、盲肠、结肠和直肠中脱氧核糖核酸合成的昼夜节律依赖性刺激作用。
Endocrinology. 1980 May;106(5):1498-503. doi: 10.1210/endo-106-5-1498.
5
The effect of epidermal growth factor on wound healing in mice.表皮生长因子对小鼠伤口愈合的影响。
J Surg Res. 1982 Aug;33(2):164-9. doi: 10.1016/0022-4804(82)90024-5.
6
Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.人血浆表皮生长因子/β-尿抑胃素与血小板有关。
J Clin Invest. 1983 Jul;72(1):249-59. doi: 10.1172/jci110964.
7
Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins.编码表皮生长因子及七种相关蛋白的小鼠颌下信使核糖核酸的结构
Science. 1983 Jul 15;221(4607):236-40. doi: 10.1126/science.6602382.
8
Effects of epidermal growth factor on gastrointestinal secretions.表皮生长因子对胃肠分泌物的影响。
Am J Physiol. 1984 May;246(5 Pt 1):G580-6. doi: 10.1152/ajpgi.1984.246.5.G580.
9
Characterization and repartition of epidermal growth factor-urogastrone receptors in gastric glands isolated from young and adult guinea pigs.从幼年和成年豚鼠分离的胃腺中表皮生长因子-尿抑胃素受体的特性与分布
Biochim Biophys Acta. 1984 Apr 10;798(2):192-8. doi: 10.1016/0304-4165(84)90303-9.
10
Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system.表皮生长因子的肝内潴留和胆汁分泌:高容量摄取系统的证据。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3797-801. doi: 10.1073/pnas.80.12.3797.