Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.
Clin Hemorheol Microcirc. 2022;81(4):359-371. doi: 10.3233/CH-211290.
Beside the role of ABO group in immunohaematology, there is accumulating evidence that the ABO blood group also plays a key role in various human disorders. The interest in blood groups and their association with disease stems from the awareness that blood group antigens are incredibly important components in the process of cell maturation and control. Studies have indicated a link between cancer and the ABO blood group. The appearance or disappearance of blood type antigens is now considered a hallmark of malignancy in many common cancers. Several tumour markers are in fact known blood group antigens. The aim of this review is to describe the history and possible functions of the ABO group and then summarize the association between blood groups and skin cancers.
除了在免疫血液学中的作用外，越来越多的证据表明 ABO 血型在各种人类疾病中也起着关键作用。人们对血型及其与疾病的关联产生兴趣，是因为意识到血型抗原是细胞成熟和控制过程中非常重要的组成部分。研究表明，癌症与 ABO 血型之间存在关联。在许多常见癌症中，血型抗原的出现或消失现在被认为是恶性肿瘤的一个标志。事实上，有几个肿瘤标志物就是已知的血型抗原。本文的目的是描述 ABO 血型的历史和可能的功能，然后总结血型与皮肤癌之间的关联。
