血小板指标不影响ABO血型对肺腺癌易感性的影响。

Platelet indicators do not influence the impact of ABO blood groups on lung adenocarcinoma susceptibility.

作者信息

Zhang Ting, Xiang Mingfei, Yin Hailin, Dan Jiaqiang, Zu Ruiling, Rao Lubei, Zhang Peiying, Wang Yuan, Yang Ran, Zhang Yun, Luo Huaichao

机构信息

School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, People's Republic of China.

Medical Insurance Division, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

出版信息

Sci Rep. 2025 Jan 7;15(1):1131. doi: 10.1038/s41598-024-82910-w.

DOI:10.1038/s41598-024-82910-w

PMID:39775021

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706952/

Abstract

The aim of this study was to investigate the role of platelet indicators in the susceptibility of ABO blood groups to lung adenocarcinoma. This was a multicenter retrospective cohort analysis. The study included 528 patients diagnosed with primary lung adenocarcinoma and 528 randomly selected control group patients who were admitted to the Chengdu Fifth People's Hospital from January 2021 to September 2023. Additionally, it included 1452 patients diagnosed with primary lung adenocarcinoma and 1452 control group patients who were admitted to the Sichuan Cancer Hospital from November 2013 to May 2021. Platelet indicators were studied using an automated blood counter. ABO blood groups were determined by the gel column method using agglutination techniques. Statistical analysis was performed using Chi-square tests, independent-samples T-tests, ANOVA, and logistic regression. Chi-square analysis showed that there was a difference in ABO blood group composition between the lung adenocarcinoma group and the control group (p < 0.001). Independent-samples T-tests showed that MPV was significantly higher in lung adenocarcinoma than in control group (p = 0.025). The ANOVA of ABO blood groups and platelet indicators in lung adenocarcinoma showed that the average platelet count (PLT) of O group blood was higher than that of B group blood (p = 0.037), while the mean platelet volume (MPV) was significantly lower than that of A group, B group and AB group blood (p = 0.009). After adjusting for gender and age, logistic regression analysis showed that the risk of lung adenocarcinoma in blood groups O and B was higher than that in blood group A (p < 0.05 for each) and blood group AB (p < 0.05 for each), regardless of whether platelet indicators were added. Meanwhile, logistic regression showed that high platelet volume (MPV) was a risk factor for lung adenocarcinoma (p = 0.029). Our findings suggest that platelet indicators are respectively associated with ABO blood groups and lung adenocarcinoma. However, platelet indicators may not influence the ABO blood groups related susceptibility to Lung Adenocarcinoma.

摘要

本研究旨在探讨血小板指标在ABO血型对肺腺癌易感性中的作用。这是一项多中心回顾性队列分析。该研究纳入了2021年1月至2023年9月在成都市第五人民医院确诊的528例原发性肺腺癌患者以及528例随机选取的对照组患者。此外，还纳入了2013年11月至2021年5月在四川省肿瘤医院确诊的1452例原发性肺腺癌患者以及1452例对照组患者。使用自动血液计数器研究血小板指标。采用凝集技术通过凝胶柱法确定ABO血型。使用卡方检验、独立样本T检验、方差分析和逻辑回归进行统计分析。卡方分析表明，肺腺癌组和对照组的ABO血型组成存在差异（p < 0.001）。独立样本T检验表明，肺腺癌患者的平均血小板体积（MPV）显著高于对照组（p = 0.025）。对肺腺癌患者的ABO血型和血小板指标进行方差分析显示，O型血的平均血小板计数（PLT）高于B型血（p = 0.037），而平均血小板体积（MPV）显著低于A型血、B型血和AB型血（p = 0.009）。在调整性别和年龄后，逻辑回归分析表明，无论是否添加血小板指标，O型血和B型血患肺腺癌的风险均高于A型血（各p < 0.05）和AB型血（各p < 0.05）。同时，逻辑回归显示高血小板体积（MPV）是肺腺癌的一个危险因素（p = 0.029）。我们的研究结果表明，血小板指标分别与ABO血型和肺腺癌相关。然而，血小板指标可能不会影响ABO血型相关的肺腺癌易感性。