Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Department of Obstetrics and Gynecology, University of Regensburg, Hospital of the Barmherzige Brueder, Clinic St Hedwig, Regensburg, Germany.
Am J Reprod Immunol. 2022 Mar;87(3):e13519. doi: 10.1111/aji.13519. Epub 2022 Jan 12.
The aim of this study was to evaluate the soluble programmed death-ligand (sPD-L1) and soluble B7-H4 (sB7-H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies. METHOD OF THE STUDY: sPD-L1 and sB7-H4 levels were determined with enzyme-linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7-H4 and sPD-L1 measurements in each trimester of pregnancy.
During the course of pregnancy, the sB7-H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD-L1 levels increased significantly over the course of pregnancy.
The highest serum levels of sPD-L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7-H4 concentration levels in second trimester suggests different profile of T-cell regulation in physiological pregnancy.
本研究旨在评估复杂妊娠三个孕期中可溶性程序性死亡配体（sPD-L1）和可溶性 B7-H4（sB7-H4）的血清浓度水平。
采用酶联免疫吸附试验（ELISA）测定 sPD-L1 和 sB7-H4 水平。根据妊娠三个月将患者（n=26）分为三组。在纳入研究的 26 名妇女中，14 名妇女在妊娠的每个三个月都进行了纵向 sB7-H4 和 sPD-L1 测量。
在妊娠过程中，第二孕期 sB7-H4 血清水平明显高于第一和第三孕期，而 sPD-L1 水平随着妊娠的进行而显著升高。
第三孕期 sPD-L1 血清水平最高提示整个孕期母体免疫抑制逐渐增强，而第二孕期 sB7-H4 浓度升高提示生理性妊娠中 T 细胞调节的不同特征。
