Mach Pawel, Gellhaus Alexandra, Wicherek Lukasz, Schmidt Boerge, Kimmig Rainer, Kasimir-Bauer Sabine, Köninger Angela
Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
Department of Gynecology and Oncology and Gynecological Nursing, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Am J Reprod Immunol. 2015 Sep;74(3):209-15. doi: 10.1111/aji.12392. Epub 2015 Apr 24.
B7-H4, a transmembrane protein that negatively regulates T lymphocytes, seems to play a role in the suppression of the im\mune response at the maternal-fetal interface. The aim of this study was to compare the blood serum concentration levels of soluble B7-H4 (sB7-H4) prepartal and postpartal in both women who experienced spontaneous onset of labor and those who underwent elective cesarian section.
Blood was obtained from 30 prepartal and postpartal women who delivered at the University Hospital of Essen between 2011 and 2012. These patients were further divided into two subgroups depending on the advancement of labor. The sB7-H4 blood serum concentration levels of the women in the groups were then determined by ELISA (BIOZOL, Eching, Germany).
In women who underwent elective cesarian section, a significant increase in sB7-H4 blood serum concentration levels occurred postpartal, while in women who experienced spontaneous onset of labor, no differences between prepartal and postpartal concentration levels were observed. The sB7-H4 blood serum concentration levels on the day after delivery in the women who experienced spontaneous labor and those who underwent elective cesarian section were comparable; however, higher blood serum concentration levels of sB7-H4 were observed prepartal in women with spontaneous onset of labor compared to those found in the women about to undergo elective cesarian section.
These changes in sB7-H4 blood serum concentration levels suggest that this protein is involved in immunological changes associated with the spontaneous onset of labor and post-delivery homeostasis.
B7-H4是一种对T淋巴细胞起负向调节作用的跨膜蛋白，似乎在母胎界面免疫反应的抑制中发挥作用。本研究的目的是比较自然分娩和择期剖宫产的女性产前和产后血清可溶性B7-H4（sB7-H4）的浓度水平。
采集了2011年至2012年间在埃森大学医院分娩的30名女性产前和产后的血液。这些患者根据产程进展进一步分为两个亚组。然后通过ELISA（德国艾兴市BIOZOL公司）测定各组女性的sB7-H4血清浓度水平。
在择期剖宫产的女性中，产后sB7-H4血清浓度水平显著升高，而在自然分娩的女性中，未观察到产前和产后浓度水平的差异。自然分娩和择期剖宫产的女性在分娩后一天的sB7-H4血清浓度水平相当；然而，与即将进行择期剖宫产的女性相比，自然分娩的女性产前sB7-H4血清浓度水平更高。
sB7-H4血清浓度水平的这些变化表明，该蛋白参与了与自然分娩和产后内环境稳态相关的免疫变化。
