[Immunopathological manifestations of systemic lupus erythematosus and their correction during long-term dispensary observation].

The time course of immunopathological symptoms of lupus erythematosus was studied in 117 patients over a period of 5 years. It was established that routine multimodality therapy while resulting in a positive time course of clinical and clinico-biochemical indices, did not ensure the normalization of immunological parameters, particularly of the T-system of immunity. Courses of theophylline and splenin therapy were added to multimodality therapy to raise therapeutic efficacy and to return to normal the status of the immune system. A regular follow-up made it possible to stabilize the disease in 82.1% of the LE patients and to preserve working capacity in 50.4% of them.