[The possibilities of selecting an adequate therapy of systemic lupus erythematosus based on the results of HLA typing].

In order to find out the most suitable treatment for systemic lupus erythematodes the frequency of various antigens in the locus A and B of the system HLA was examined in various clinical subgroups of patients with systemic lupus erythematodes. A correlation was established between the group of patient treated intensively and the antigens HLA-A11, HLA-B18, HLA-B8. The antigens HLA-B35 and HLA-B5 were associated with the group of patients treated with a moderately intensive treatment for systemic lupus erythematodes. The patients with systemic lupus erythematodes with antigens HLA-A11, HLA-B18 and HLA-B8 should be actively treated from the onset of the disease in order to avoid severe lesions of the kidneys and the CNS and the polysyndrome clinical manifestations.