Marine College, Shandong University, Weihai, Shandong, 264209, China.
Zhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, 519041, China.
J Biomed Nanotechnol. 2021 Dec 1;17(12):2319-2337. doi: 10.1166/jbn.2021.3202.
Topical drug delivery methods are important in the treatment of skin diseases. Drug nanocrystals, which are nanometersized particles of active pharmaceutical ingredients, offer efficient topical delivery with high stability, high drug loading capacity, steady dissolution, and sustained drug release profiles. The use of nanocrystals for the topical delivery of skin disease therapies is currently being evaluated; this review focuses on how nanocrystals facilitate active pharmaceutical ingredient transport across skin barriers, exploring the underlying transportation mechanisms of the nanocrystals and active pharmaceutical ingredient molecules to the dermal and epidermal skin cells. In topical delivery, previous skin treatments, choice of excipients and vehicles, and penetration enhancement strategies critically influence the topical delivery of drug nanocrystals. Various research and applications of drug nanocrystals in skin disease therapy are highlighted in this review, and intellectual property protection for drug nanocrystal formulations, clinical trial data, and products with commercial potential are also discussed.
局部给药方法在皮肤病治疗中很重要。药物纳米晶体是指活性药物成分的纳米级颗粒，具有高效的局部递送、高稳定性、高载药量、稳定的溶解和持续的药物释放特性。目前正在评估纳米晶体在皮肤病治疗中的局部递送，本综述重点探讨了纳米晶体如何促进活性药物成分穿过皮肤屏障的运输，研究了纳米晶体和活性药物成分分子向皮肤真皮和表皮细胞转运的潜在运输机制。在局部给药中，以前的皮肤治疗方法、赋形剂和载体的选择以及渗透增强策略会极大地影响药物纳米晶体的局部递送。本文综述了药物纳米晶体在皮肤病治疗中的各种研究和应用，并讨论了药物纳米晶体制剂的知识产权保护、临床试验数据和具有商业潜力的产品。
