Henze E
Z Kardiol. 1987 May;76(5):255-8.
Positron emission computed tomography (PET) has introduced a new dimension into cardiology by its ability of imaging in-vivo cardiac metabolism non-invasively. Following administration of labelled substrates PET provides display of digitized heart tomograms, which reflect tracer concentration quantitatively. Thus, regional myocardial metabolism and perfusion can be measured using appropriate tracers such as C-11 palmitate, F-18 deoxyglucose, N-13 or C-11 amino acids, N-13 ammonia and Rb-82. Accordingly, the documentation of marked metabolic derangements during ischemia and infarction by initial clinical PET studies have been very promising diagnostically. It has been shown that normal, resting ischemic and acutely ischemic and infarcted tissue can be differentiated reliably. In cardiomyopathies, disturbed energy substrate utilization not known until then was found by means of PET. Unfortunately, PET will be available only in larger centers in the near future because of its high cost.
正电子发射计算机断层扫描（PET）通过其无创性体内心脏代谢成像能力，为心脏病学带来了新的维度。在给予标记底物后，PET可提供数字化心脏断层图像的显示，这些图像能定量反映示踪剂浓度。因此，使用适当的示踪剂，如C-11棕榈酸、F-18脱氧葡萄糖、N-13或C-11氨基酸、N-13氨和Rb-82，可测量局部心肌代谢和灌注。相应地，最初的临床PET研究对缺血和梗死期间明显代谢紊乱的记录在诊断方面非常有前景。研究表明，正常、静息缺血、急性缺血和梗死组织能够可靠地区分。在心肌病中，借助PET发现了此前未知的能量底物利用紊乱情况。不幸的是，由于成本高昂，PET在不久的将来仅能在较大的中心使用。
