Potapova V A, Trubnikov V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(5):727-32.
The authors studied the relationship between the clinical parameters of schizophrenia and the immunological parameters as exemplified by the B-system of immunity. An analysis was conducted with the use of linear correlation coefficients whose sum (a correlational matrix) was subjected to a cluster analysis. The data obtained indicate a considerable increase in both levels and activity of B-lymphocytes in schizophrenic patients in an acute psychotic state. The characteristics of slowly-progressive schizophrenia distinguished by a torpid relatively benign course and mild mental disturbances also appear to determine a relatively mild nature of aberrations in the immunological status of the patients. The studied immunological parameters were found to correlate with the patients' age at the onset of the disease and at the time of psychosis manifestations. The authors supposed that the immunologic characteristics definitely correlated with the severity of the disease exacerbation, form, and gravity, while the degree of deviation of immunologic parameters from the norm makes it possible to better assess the nature of psychopathologic manifestations in schizophrenia.
作者研究了精神分裂症的临床参数与以免疫B系统为例的免疫参数之间的关系。使用线性相关系数进行分析，其总和（相关矩阵）进行聚类分析。获得的数据表明，处于急性精神病状态的精神分裂症患者的B淋巴细胞水平和活性均显著增加。以进展缓慢、病程相对良性且精神障碍较轻为特征的缓慢进展型精神分裂症，似乎也决定了患者免疫状态异常的性质相对较轻。研究发现，所研究的免疫参数与疾病发作时和精神病表现时患者的年龄相关。作者推测，免疫特征肯定与疾病加重的严重程度、形式和严重性相关，而免疫参数偏离正常的程度有助于更好地评估精神分裂症精神病理表现的性质。
