Chapuy M C, Chapuy P, Meunier P J
Am J Clin Nutr. 1987 Aug;46(2):324-8. doi: 10.1093/ajcn/46.2.324.
Calcium and vitamin D status were studied in 193 healthy elderly French people. Calcium intake was less than 500 mg/d in 62% of the patients and the vitamin D intake was less than 5 micrograms/d in all patients. They also exhibited reduced levels of serum calcium (SCa) and 25-hydroxyvitamin D (25-OHD) and high levels of parathyroid hormone (PTH) and alkaline phosphatase (SAP). The response to calcium (1000 mg/d) and ergocalciferol (20 micrograms/d) supplementation given for 6 mo was evaluated in 65 patients with 69 subjects taken as controls. The treatment induced a significant increase in SCa and in 25-OHD levels, and a subsequent decrease in PTH levels without modification of the mean calcitriol levels. The biochemical changes were more marked in long-stay hospital patients than in outpatients. All these changes were significantly different from those observed in the control group. Increasing the calcium and vitamin D intake reduces the biochemical signs of secondary hyperparathyroidism in elderly people.
对193名健康的法国老年人的钙和维生素D状况进行了研究。62%的患者钙摄入量低于500毫克/天，所有患者的维生素D摄入量均低于5微克/天。他们还表现出血清钙（SCa）和25-羟维生素D（25-OHD）水平降低，甲状旁腺激素（PTH）和碱性磷酸酶（SAP）水平升高。对65例患者补充钙（1000毫克/天）和麦角钙化醇（20微克/天）6个月的反应进行了评估，以69名受试者作为对照。治疗导致SCa和25-OHD水平显著升高，随后PTH水平降低，而平均骨化三醇水平未发生改变。长期住院患者的生化变化比门诊患者更明显。所有这些变化与对照组观察到的变化有显著差异。增加钙和维生素D的摄入量可减轻老年人继发性甲状旁腺功能亢进的生化体征。
