Baglin A, Prinseau J, Alterescu R, Franc B, Nochy D, Goguel A
Ann Med Interne (Paris). 1987;138(3):189-92.
A nephrotic syndrome due to membranous nephropathy and B chronic lymphocytic leukemia were simultaneously discovered in a 52 year old patient. Proteinuria was significantly reduced with chlorambucil therapy and nephrotic syndrome disappeared. Treatment withdrawal for 5 months resulted in a significant lowering of serum albumin level, while blood lymphocyte count increased. These observations indicate a probable causal relationship between the lymphoproliferative disease and the onset of the glomerulopathy which is supported by the efficacy of the chemotherapy on the evolution of the nephrotic syndrome.
一名52岁患者同时被发现患有由膜性肾病引起的肾病综合征和B细胞慢性淋巴细胞白血病。使用苯丁酸氮芥治疗后蛋白尿显著减少，肾病综合征消失。停药5个月导致血清白蛋白水平显著降低，而血淋巴细胞计数增加。这些观察结果表明淋巴细胞增殖性疾病与肾小球病的发病之间可能存在因果关系，化疗对肾病综合征进展的疗效支持了这一点。
