Lambré Claude, Barat Baviera José Manuel, Bolognesi Claudia, Cocconcelli Pier Sandro, Crebelli Riccardo, Gott David Michael, Grob Konrad, Lampi Evgenia, Mengelers Marcel, Mortensen Alicja, Rivière Gilles, Steffensen Inger-Lise, Tlustos Christina, Van Loveren Henk, Vernis Laurence, Zorn Holger, Glandorf Boet, Herman Lieve, Aguilera Jaime, Andryszkiewicz Magdalena, Kovalkovičová Natália, Liu Yi, Chesson Andrew
EFSA J. 2021 Dec 17;19(12):e07006. doi: 10.2903/j.efsa.2021.7006. eCollection 2021 Dec.
The food enzyme rennet paste containing chymosin (EC 3.4.23.4), pepsin A (EC 3.4.23.1) and triacylglycerol lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is prepared from the abomasum of suckling goats, lambs and calves by Caglificio Clerici S.p.A. The food enzyme is intended to be used in milk processing for cheese production. As no concerns arise from the animal source of the food enzyme, from its manufacture, and based on the history of safe use and consumption, the Panel considers that toxicological data were not required and no exposure assessment was necessary. On the basis of literature data, the Panel considers that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure could not be excluded, but the likelihood is considered to be low. Based on the data provided, the Panel concludes that this food enzyme does not give rise to safety concerns under the intended conditions of use.
含有凝乳酶（EC 3.4.23.4）、胃蛋白酶A（EC 3.4.23.1）和三酰基甘油脂肪酶（三酰基甘油酰基水解酶，EC 3.1.1.3）的食品酶凝乳酶糊剂由Caglificio Clerici S.p.A.从哺乳山羊、羔羊和犊牛的皱胃中制备。该食品酶旨在用于奶酪生产的牛奶加工中。由于该食品酶的动物来源、其生产过程以及基于安全使用和消费历史均未引起担忧，专家小组认为不需要毒理学数据，也无需进行暴露评估。根据文献数据，专家小组认为，在预期使用条件下，不能排除因膳食暴露导致过敏致敏和激发反应的风险，但认为可能性较低。根据所提供的数据，专家小组得出结论，该食品酶在预期使用条件下不会引起安全问题。
