Saakov B A, Belovolova R A, Bakhutashvili V I
Biull Eksp Biol Med. 1987 Jul;104(7):73-5.
The effect of combined application of thymalin and plaferon in the prophylaxis and treatment of traumatic syndrome has been investigated in rats. The survival rate was taken as the criterion of efficiency, the mechanism of the effect obtained being estimated at the level of immunological protective factors. Traumatic shock was induced by Kennon's method in Wistar male rats weighing 200-250 g. Post-traumatic syndrome has been observed within 7 days. The combined application of thymalin and plaferon has increased the survival rate twice within the first 7 days. Immunomodulating effect of the combined application of thymalin and plaferon on the 7th day of traumatic syndrome was most marked at the level of total T-lymphocyte population, theophylline-sensitive T suppressors and lysozyme blood serum activity.
在大鼠中研究了胸腺素和胎盘球蛋白联合应用在预防和治疗创伤综合征方面的效果。将存活率作为疗效标准，在免疫保护因子水平评估所获得效果的机制。采用肯农法在体重200 - 250克的雄性Wistar大鼠中诱导创伤性休克。创伤后综合征观察7天。胸腺素和胎盘球蛋白联合应用在最初7天内使存活率提高了两倍。在创伤综合征第7天，胸腺素和胎盘球蛋白联合应用对总T淋巴细胞群体、茶碱敏感的T抑制细胞和溶菌酶血清活性水平的免疫调节作用最为显著。
