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[左丙嗪 - 胸腺素组合对脑部中毒性水肿和肿胀发展的影响]

[Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain].

作者信息

Platonov I A, Vonogel' V G, Andreeva T A

机构信息

Smolensk State Medical Academy, ul. Krupskoi 28, Perm, 214019 Russia.

出版信息

Eksp Klin Farmakol. 2004 Jan-Feb;67(1):48-50.

PMID:15079910
Abstract

The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction. The administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduces this disorder in the blood protein fractions. The antiedematous effect of the levopromazine--thymalin combination has an additive synergistic interaction.

摘要

大鼠中毒性脑水肿的发展伴随着血浆蛋白异常和γ-球蛋白组分的积累。给予左丙嗪(5毫克/千克)、胸腺素(1.2毫克/千克)或它们的组合可减轻血液蛋白组分的这种紊乱。左丙嗪-胸腺素组合的抗水肿作用具有相加协同相互作用。

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