Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China.
Front Public Health. 2021 Dec 14;9:767151. doi: 10.3389/fpubh.2021.767151. eCollection 2021.
The aim of this study was to evaluate the relationship between lifestyle habits and health-related quality of life (HRQoL) among different ages who were initially diagnosed with breast cancer (within the first 2 weeks) and to determine the contribution of lifestyle habits factors on HRQoL. Patients with breast cancer were recruited from 22 hospitals in 11 provinces or municipalities in northern and eastern China. The Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) was used to measure HRQoL. Chi-square test, ANOVA, and multivariable generalized linear models were conducted to identify the differences in HRQoL between two age groups (age <50 years and ≥50 years) and to evaluate the contribution of lifestyle habits factors on HRQoL of patients with breast cancer. About 1,199 eligible patients with breast cancer were used for analysis. Younger women (aged <50 years) appeared to show lower scores than older women (aged ≥50 years) in HRQoL subscales, including emotional well-being ( = 0.003), functional well-being ( = 0.006), breast cancer subscale ( = 0.038), and FACT-B Total scores ( = 0.028). Tea and alcohol consumption and being very satisfied with sleep and current life were the strongest predictors of higher HRQoL in younger group. Meanwhile, no coffee consumption, frequent participation in physical activities, high sleep satisfaction, and current life satisfaction were the key predictors of higher HRQoL in older women with breast cancer. The relationship of the nine lifestyle habit items with HRQoL differed among younger and older women. The associated variable of low HRQoL can help clinicians take intervention early in order to improve the prognosis of patients with breast cancer.
本研究旨在评估不同年龄段初诊乳腺癌（发病后 2 周内）患者的生活方式习惯与健康相关生活质量（HRQoL）之间的关系，并确定生活方式习惯因素对 HRQoL 的贡献。从中国北部和东部 11 个省或直辖市的 22 家医院招募乳腺癌患者。采用癌症治疗功能评估-乳腺癌（FACT-B）量表来衡量 HRQoL。采用卡方检验、方差分析和多变量广义线性模型来比较两个年龄组（<50 岁和≥50 岁）之间的 HRQoL 差异，并评估生活方式习惯因素对乳腺癌患者 HRQoL 的贡献。约 1199 名符合条件的乳腺癌患者纳入分析。年轻女性（<50 岁）的 HRQoL 子量表评分，包括情感健康（ = 0.003）、功能健康（ = 0.006）、乳腺癌子量表（ = 0.038）和 FACT-B 总分（ = 0.028），均低于年长女性（≥50 岁）。饮茶和饮酒以及对睡眠和当前生活非常满意是年轻组 HRQoL 较高的最强预测因素。与此同时，不喝咖啡、经常参加体育活动、高睡眠满意度和对当前生活的满意是乳腺癌年长女性 HRQoL 较高的关键预测因素。9 种生活方式习惯与 HRQoL 的关系在年轻和年长女性中有所不同。低 HRQoL 的相关变量有助于临床医生早期采取干预措施，以改善乳腺癌患者的预后。
