CPEB4通过上调肾细胞癌中p21 mRNA稳定性来抑制细胞增殖。
CPEB4 Inhibit Cell Proliferation via Upregulating p21 mRNA Stability in Renal Cell Carcinoma.
作者信息
Di Jiehui, Wang Hui, Zhao Zhongjun, Zhao Guang, Qin Xiaobing, Han Zhengxiang, Liu Yong
机构信息
Cancer Institute, Xuzhou Medical University, Xuzhou, China.
Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
出版信息
Front Cell Dev Biol. 2021 Dec 16;9:687253. doi: 10.3389/fcell.2021.687253. eCollection 2021.
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) has been reported to be dysregulated in a variety of cancers and seems to play paradoxical roles in different cancers. However, the functional roles of CPEB4 in Renal cell carcinoma (RCC) are still unclear. This study aims to explore the role and underlying mechanism of CPEB4 in RCC. We found that the relative expression level of CPEB4 is down-regulated in RCC tissues and cell lines, and the low CPEB4 expression is correlated with short overall and disease-free survival of RCC patients. CPEB4 significantly inhibits RCC tumor growth both and . CPEB4 exerts an anti-tumor effect by increasing p21 mRNA stability and inducing G1 cell cycle arrest in RCC. Our data revealed that CPEB4 is a tumor suppressor gene that restrains cell cycle progression upstream of p21 in RCC. These findings revealed that CPEB4 may become a promising predictive biomarker for prognosis in patients with RCC.
据报道，细胞质聚腺苷酸化元件结合蛋白4（CPEB4）在多种癌症中表达失调，且在不同癌症中似乎发挥着矛盾的作用。然而，CPEB4在肾细胞癌（RCC）中的功能作用仍不清楚。本研究旨在探讨CPEB4在RCC中的作用及潜在机制。我们发现，CPEB4在RCC组织和细胞系中的相对表达水平下调，且CPEB4低表达与RCC患者较短的总生存期和无病生存期相关。CPEB4在体内和体外均能显著抑制RCC肿瘤生长。CPEB4通过增加p21 mRNA稳定性并诱导RCC细胞G1期细胞周期阻滞发挥抗肿瘤作用。我们的数据表明，CPEB4是一种肿瘤抑制基因，在RCC中p21上游抑制细胞周期进程。这些发现表明，CPEB4可能成为RCC患者预后的一个有前景的预测生物标志物。
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