Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Jul;32(13):1038-1033. doi: 10.13201/j.issn.1001-1781.2018.13.021.
Cytoplasmic polyadenylation element binding protein 4 (Cytoplasmic polyadenylation element binding protein 4, CPEB4) ,a newly discovered member of the cytoplasmic polyadenylation element binding proteins, is a kind of RNA binding proteins with mediator of mRNA cytoplasmic polyadenylation and translation. CPEB4 plays an important role in the proliferation, migration, invasion and interstitial transformation of many tumors. In recent years, studies have shown that CPEB4 has abnormal expression in a variety of human tumors, and the abnormal expression of cancer patients has a significant correlation with the prognosis. Based on the current research progress, the purpose of this article is to further understand the relationship between CPEB4 and malignant tumor and its molecular mechanism of regulating tumorigenesis and to provide a new direction and means for the molecular diagnosis and targeted therapy of malignant tumor.
细胞质聚腺苷酸化元件结合蛋白4（Cytoplasmic polyadenylation element binding protein 4，CPEB4）是细胞质聚腺苷酸化元件结合蛋白新发现的成员，是一种具有mRNA细胞质聚腺苷酸化及翻译调节作用的RNA结合蛋白。CPEB4在多种肿瘤的增殖、迁移、侵袭及间质转化中发挥重要作用。近年来，研究表明CPEB4在多种人类肿瘤中存在异常表达，且癌症患者的异常表达与预后显著相关。基于目前的研究进展，本文旨在进一步了解CPEB4与恶性肿瘤的关系及其调控肿瘤发生的分子机制，为恶性肿瘤的分子诊断及靶向治疗提供新的方向和手段。
