Sun Hao-Ting, Wen Xin, Han Tian, Liu Zhen-Hua, Li Shao-Bo, Wang Ji-Gang, Liu Xiu-Ping
Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Canton, Guangdong Province, People's Republic of China.
Onco Targets Ther. 2015 Nov 26;8:3499-506. doi: 10.2147/OTT.S87587. eCollection 2015.
Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.
Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.
High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).
High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.
细胞质聚腺苷酸化元件结合蛋白（CPEBs）是一类RNA结合蛋白，可通过诱导细胞质聚腺苷酸化来调节翻译过程。已有报道称CPEB4与多种癌症的肿瘤生长、血管生成及侵袭相关。迄今为止，尚未见关于CPEB4表达与乳腺癌临床预后关系的报道。我们旨在研究CPEB4在乳腺浸润性导管癌中的表达及其预后意义。
对107例浸润性导管癌（IDC）样本进行CPEB4以及雌激素受体、孕激素受体和人表皮生长因子受体的免疫组织化学染色，并评估其预后意义。
在48.6%的IDC样本中观察到CPEB4高表达。CPEB4表达升高可能与组织学分级增加（P=0.037）和N分期增加（P<0.001）有关。CPEB4高表达的患者总生存期较短（P=0.001）。CPEB4高表达是总生存期的独立预后因素（P=0.022，风险比=4.344，95%置信区间=1.235-15.283）。
CPEB4高表达与组织学分级增加和N分期增加相关，并且可作为IDC的独立预后因素。
