Payet David, Adjibade Moufidath, Baudry Julia, Ghozal Manel, Camier Aurore, Nicklaus Sophie, Adel-Patient Karine, Divaret-Chauveau Amandine, Gauvreau-Béziat Julie, Vin Karine, Lioret Sandrine, Charles Marie Aline, Kesse-Guyot Emmanuelle, de Lauzon-Guillain Blandine
Université de Paris, Inserm, INRAE, CRESS, Paris, France.
Université Sorbonne Paris Nord, Inserm, INRAE, CNAM, CRESS, Paris, France.
Front Nutr. 2021 Dec 16;8:791430. doi: 10.3389/fnut.2021.791430. eCollection 2021.
To assess (1) whether a history of allergy is associated with feeding with organic foods (OFs) during the complementary feeding period and (2) whether OF consumption in infancy is related to the incidence of respiratory and allergic diseases up to age 5.5 years. Analyses involved more than 8,000 children from the nationwide É (ELFE) birth cohort. Associations between family or infant history of allergy and frequency of OF consumption during the complementary feeding period were assessed with multinomial logistic regression. Associations between OF consumption in infancy and respiratory or allergic diseases between age 1 and 5.5 years were assessed with logistic regression. A family history of allergy or cow's milk protein allergy at age 2 months was strongly and positively related to feeding with OF during the complementary feeding period. Feeding with OF during the complementary feeding period was not related to respiratory diseases or eczema up to age 5.5 years. Compared to infrequent consumption of both organic and commercial complementary foods, frequent OF consumption without commercial complementary foods was associated with a higher risk of food allergy, whereas frequent commercial complementary food consumption without OF use was associated with a lower risk of food allergy. This study suggests that a history of allergy strongly affects feeding with OF during the complementary feeding period. However, OF consumption was not associated with reduced odds of food allergy later in childhood but could be associated with increased odds, which should be examined more deeply.
（1）过敏史是否与辅食添加期食用有机食品（OFs）有关；（2）婴儿期食用OFs是否与5.5岁前呼吸道和过敏性疾病的发病率有关。分析涉及来自全国范围的E（ELFE）出生队列的8000多名儿童。采用多项逻辑回归评估过敏的家族史或婴儿史与辅食添加期OFs食用频率之间的关联。采用逻辑回归评估婴儿期食用OFs与1至5.5岁之间的呼吸道或过敏性疾病之间的关联。2个月大时的过敏家族史或牛奶蛋白过敏与辅食添加期食用OFs呈强烈正相关。辅食添加期食用OFs与5.5岁前的呼吸道疾病或湿疹无关。与很少同时食用有机和商业辅食相比，经常只食用OFs而不食用商业辅食与食物过敏风险较高有关，而经常只食用商业辅食而不食用OFs与食物过敏风险较低有关。这项研究表明，过敏史在辅食添加期对食用OFs有强烈影响。然而，食用OFs与儿童后期食物过敏几率降低无关，但可能与几率增加有关，这一点应更深入地研究。
