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来自意大利中部的100名1型(胰岛素依赖型)糖尿病患者的HLA分型数据显示,与DR5呈负相关,而非与DR2呈负相关。

HLA typing data on 100 type 1 (insulin-dependent) diabetic patients from central Italy show a negative association with DR5 rather than with DR2.

作者信息

Vela M, Adorno D, Longo A, Papola F, Maccarone D, Centis D, Raponi M P, Candela A, Campea L, Orsini M

出版信息

Clin Immunol Immunopathol. 1987 Oct;45(1):143-6. doi: 10.1016/0090-1229(87)90121-8.

DOI:10.1016/0090-1229(87)90121-8
PMID:3497749
Abstract

HLA typing of 100 Type 1 diabetic patients from the Rome area confirmed the strong association with DR3 and DR4 and the prevalence of DR3/4 heterozygotes. However, DR5 rather than DR2 showed a significantly negative association.

摘要

对来自罗马地区的100名1型糖尿病患者进行的HLA分型证实了其与DR3和DR4的强关联以及DR3/4杂合子的患病率。然而,与DR2相比,DR5显示出显著的负相关。

相似文献

1
HLA typing data on 100 type 1 (insulin-dependent) diabetic patients from central Italy show a negative association with DR5 rather than with DR2.来自意大利中部的100名1型(胰岛素依赖型)糖尿病患者的HLA分型数据显示,与DR5呈负相关,而非与DR2呈负相关。
Clin Immunol Immunopathol. 1987 Oct;45(1):143-6. doi: 10.1016/0090-1229(87)90121-8.
2
Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective.胰岛素依赖型糖尿病的遗传易感性与HLA - DR1相关,而DR5具有保护作用。
Autoimmunity. 1988;1(3):197-205. doi: 10.3109/08916938808997164.
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HLA-antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease.意大利1型糖尿病患者的HLA抗原:DR3/DR4抗原及母乳喂养在疾病发病中的作用
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HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A negative association with DR5 rather than DR2?
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Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients.HLA-DQw3(TA10-)与I型糖尿病的关联发生在DR3/4患者中,而DR1/4患者则不然。
Diabetes. 1988 Jul;37(7):926-9. doi: 10.2337/diab.37.7.926.
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Organ-specific autoimmunity and HLA-DR antigens as markers for beta-cell destruction in patients with type II diabetes.器官特异性自身免疫和HLA - DR抗原作为II型糖尿病患者β细胞破坏的标志物。
Diabetes. 1988 Jan;37(1):99-103. doi: 10.2337/diab.37.1.99.
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HLA A, B, and DR antigens and complotype in Tunisian patients with diabetes mellitus.
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The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association.1型(胰岛素依赖型)糖尿病的遗传易感性:HLA-DR关联分析。
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[Lyme disease and HLA-DR antigens: relation between HLA-DR2 and HLA-DR4].[莱姆病与HLA - DR抗原:HLA - DR2与HLA - DR4之间的关系]
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Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus.II类人类白细胞抗原在暴发性和典型自身免疫性1型糖尿病中的不同作用。
Diabetologia. 2005 Feb;48(2):294-300. doi: 10.1007/s00125-004-1626-x. Epub 2005 Feb 2.

引用本文的文献

1
HLA-DQ screening for risk assessment of insulin dependent diabetes in northern Italy.意大利北部用于胰岛素依赖型糖尿病风险评估的HLA - DQ筛查
Acta Diabetol. 1995 Oct;32(3):137-42. doi: 10.1007/BF00838481.
2
HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A negative association with DR5 rather than DR2?
Acta Diabetol Lat. 1990 Jul-Sep;27(3):223-30. doi: 10.1007/BF02581334.
3
HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study.HLA-DQβ链限制性片段长度多态性作为1型(胰岛素依赖型)糖尿病的风险标志物:一项芬兰家族研究。
Diabetologia. 1990 Jun;33(6):357-62. doi: 10.1007/BF00404640.
4
HLA-antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease.意大利1型糖尿病患者的HLA抗原:DR3/DR4抗原及母乳喂养在疾病发病中的作用
Acta Diabetol. 1992;28(3-4):229-32. doi: 10.1007/BF00779004.