Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea, #06974.
Graefes Arch Clin Exp Ophthalmol. 2022 Apr;260(4):1139-1145. doi: 10.1007/s00417-021-05454-z. Epub 2022 Jan 2.
To evaluate the difference between the incidences of sterile endophthalmitis after administration of intravitreal aflibercept injection using two different types of syringes.
We administered a total of 498 intravitreal aflibercept injections between September 2017 and August 2021. The disposable syringe used was changed from a 1-mL disposable syringe (Profi syringe, Shinchang Medical., Ltd. Korea) to a 1-mL Becton Dickenson Luer-Lok syringe (BD, Franklin, NJ, USA) in September 2019. Thus, the patients who received injections before and after September 1, 2019, were classified into group 1 and group 2, respectively. The incidence of aflibercept-related sterile endophthalmitis between the two groups was compared.
In group 1, six (2.791%) out of 215 cases were diagnosed with sterile endophthalmitis and prescribed topical or oral steroids. In group 2, one (0.353%) out of 283 cases was diagnosed with sterile endophthalmitis and prescribed a steroid eye drop. The incidence of sterile endophthalmitis was significantly different between the two groups (P = 0.046).
The BD Luer-Lok syringe is associated with a lower incidence of aflibercept-related sterile endophthalmitis than the conventional polypropylene syringe. Differences in immunogenicity associated with silicone oil lubricants within the syringes might be one of the potential reasons behind the difference in the incidence of the sterile endophthalmitis.
评估使用两种不同类型注射器进行玻璃体内注射阿柏西普后无菌性眼内炎发生率的差异。
我们于 2017 年 9 月至 2021 年 8 月期间共进行了 498 例玻璃体内注射阿柏西普。2019 年 9 月，我们将一次性注射器由 1 mL 一次性注射器（Profi 注射器，Shinchang Medical.，Ltd. Korea）更换为 1 mL Becton Dickenson Luer-Lok 注射器（BD，Franklin，NJ，USA）。因此，将 2019 年 9 月 1 日之前和之后接受注射的患者分别归入第 1 组和第 2 组。比较两组之间阿柏西普相关无菌性眼内炎的发生率。
在第 1 组中，215 例患者中有 6 例（2.791%）诊断为无菌性眼内炎，并开具了局部或口服皮质类固醇。在第 2 组中，283 例患者中有 1 例（0.353%）诊断为无菌性眼内炎，并开具了皮质类固醇眼药水。两组之间无菌性眼内炎的发生率存在显著差异（P=0.046）。
与传统的聚丙烯注射器相比，BD Luer-Lok 注射器与阿柏西普相关无菌性眼内炎发生率较低。注射器内硅油润滑剂的免疫原性差异可能是无菌性眼内炎发生率差异的潜在原因之一。
