Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Eur J Clin Microbiol Infect Dis. 2022 Mar;41(3):415-420. doi: 10.1007/s10096-021-04389-x. Epub 2022 Jan 3.
This study is to evaluate the clinical characteristics and outcomes of Enterococcus raffinosus bacteremia in adults. We analyzed the medical records of adult patients with E. raffinosus bacteremia who were diagnosed and treated between 1997 and 2020 at a tertiary care teaching hospital in Seoul, Republic of Korea. The demographic, clinical, and laboratory data were collected and assessed. A total of 49 cases of E. raffinosus bacteremia were identified. E. raffinosus accounted for 0.6% of all enterococcal bacteremia events, and the incidence was 0.02 cases per 1,000 admissions. Of the 49 cases of E. raffinosus bacteremia, 35 (71.4%) had underlying malignancy. The biliary tract was the most common source of infection (81.6%, 40/49) and polymicrobial bacteremia was found in 25 cases (51.0%). The resistance rates of E. raffinosus bacteremia cases to penicillin, ampicillin, vancomycin, and linezolid were 61.2%, 49.0%, 2.0%, and 0%, respectively. In our case series, there was one case of vanA-type vancomycin-resistant E. raffinosus. The all-cause 60-day mortality rate was 22.4% (11/49), and the E. raffinosus bacteremia-related mortality rate was 4.1% (2/49). Cases of E. raffinosus bacteremia mainly originated from biliary tract infection and had a low rate of bacteremia-related mortality.
本研究旨在评估成人粪肠球菌菌血症的临床特征和结局。我们分析了 1997 年至 2020 年期间在韩国首尔一家三级教学医院诊断和治疗的成人粪肠球菌菌血症患者的病历。收集并评估了人口统计学、临床和实验室数据。共确定了 49 例粪肠球菌菌血症。粪肠球菌占肠球菌菌血症事件的 0.6%，发病率为每 1000 例住院患者 0.02 例。49 例粪肠球菌菌血症中，35 例（71.4%）有基础恶性肿瘤。胆道是最常见的感染源（81.6%，40/49），25 例（51.0%）为混合菌血症。粪肠球菌菌血症对青霉素、氨苄西林、万古霉素和利奈唑胺的耐药率分别为 61.2%、49.0%、2.0%和 0%。在我们的病例系列中，有 1 例 vanA 型万古霉素耐药粪肠球菌。全因 60 天死亡率为 22.4%（11/49），粪肠球菌菌血症相关死亡率为 4.1%（2/49）。粪肠球菌菌血症主要来源于胆道感染，菌血症相关死亡率较低。
