Hunter R E, Doherty P, Griffin T W, Gionet M, Hnatowich D J, Bianco J A, Dillon M B
Gynecol Oncol. 1987 Jul;27(3):325-39. doi: 10.1016/0090-8258(87)90254-x.
This is a preliminary study to evaluate the utility of using the monoclonal antibody (CO-125) labeled with indium-111 to image recurrences of ovarian cancer. This technique has been investigated in 23 patients with ovarian cancer and the results have been compared with blood OC-125 levels, CT scans, and findings at second-look surgery. Following infusion of 1 mg of F(ab')2 fragments (1-2 mCi 111In), quantitative SPECT and planar imaging was obtained daily for 72 hr along with analysis of serum. The nuclear medicine scans of the tumor site recurrences were technically excellent. When compared to second-look laparotomy, there were 2 true negatives, 2 false positives, 14 true positives, and 2 false negatives by nuclear imaging. CT scans correlated less well with surgery, but serum OC-125 levels correlate more closely with nuclear scans and second-look surgery. Those with multiple small metastatic implants showed a pattern of diffuse uptake which increased with time, whereas those with nodal or larger recurrences showed a more focal uptake. The combination of favorable biodistribution and positive images, especially in patients with normal antigen levels and negative CT scans, suggests a role for OC-125 monoclonal antibody imaging in their clinical management. However, further investigation is needed to determine whether nuclear scans can replace second-look surgery. If it can show that enough 111In-labeled antibody accumulates in the tumor site to justify radioimmunotherapy, then 90Y (a pure beta emitter) could be exchanged for 111In. This is potentially a method of radioimmunotherapy for recurrent ovarian carcinoma.
这是一项初步研究，旨在评估用铟 - 111标记的单克隆抗体（CO - 125）对卵巢癌复发进行成像的效用。该技术已在23例卵巢癌患者中进行了研究，并将结果与血OC - 125水平、CT扫描以及二次探查手术的结果进行了比较。注入1毫克F(ab')2片段（1 - 2毫居里铟 - 111）后，连续72小时每天进行定量SPECT和平面成像，并分析血清。肿瘤部位复发的核医学扫描在技术上效果良好。与二次探查剖腹术相比，核成像有2例假阴性、2例假阳性、14例真阳性和2例真阴性。CT扫描与手术的相关性较差，但血清OC - 125水平与核扫描和二次探查手术的相关性更强。有多个小转移灶的患者显示出弥漫性摄取模式，且随时间增加，而有淋巴结或较大复发灶的患者显示出更局灶性的摄取。良好的生物分布和阳性图像的结合，特别是在抗原水平正常且CT扫描阴性的患者中，表明OC - 125单克隆抗体成像在其临床管理中具有作用。然而，需要进一步研究以确定核扫描是否可以取代二次探查手术。如果能证明足够量的铟 - 111标记抗体在肿瘤部位积聚以证明放射免疫疗法合理，那么可以将90钇（一种纯β发射体）替换铟 - 111。这可能是一种复发性卵巢癌的放射免疫疗法。
