Vuillez J P, Peltier P, Mayer J C, Dubois F, Chetanneau A, Fumoleau P, Bertrand A, Chatal J F
Centre René Gauducheau, Nantes, France.
J Nucl Med. 1991 Feb;32(2):221-7.
An important criterion for the clinical use of a new imaging technique is the correct reproducibility of interpretation. Forty-six paired immunoscintigraphic examinations were performed on 43 patients with suspected ovarian carcinoma recurrence using F(ab')2 fragments of OC125 antibody labeled first with indium-111 and then with iodine-131. Planar scintigraphy (PS) and emission computed tomography (ECT) images were interpreted blindly and separately by three observers, and reproducibility was evaluated by a kappa concordance index. Intra- and interobserver reproducibility were generally satisfactory (kappa values of 0.6 and 0.7, respectively). Binomial analysis of kappa values for ECT showed the superiority of indium-111 for intraobserver (p = 0.035) and interobserver (p = 0.0039) study. However, for PS there was no significant difference in reproducibility with the two radionuclides.
一种新的成像技术临床应用的一个重要标准是解释的正确可重复性。使用首先用铟 - 111然后用碘 - 131标记的OC125抗体的F(ab')2片段，对43例疑似卵巢癌复发的患者进行了46次配对免疫闪烁检查。三位观察者分别对平面闪烁显像（PS）和发射计算机断层扫描（ECT）图像进行盲法解读，并通过kappa一致性指数评估可重复性。观察者内和观察者间的可重复性总体上令人满意（kappa值分别为0.6和0.7）。对ECT的kappa值进行二项式分析表明，铟 - 111在观察者内（p = 0.035）和观察者间（p = 0.0039）研究中具有优势。然而，对于PS，两种放射性核素在可重复性方面没有显著差异。
