Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China; Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China.
Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, Fujian, P.R. China; Fujian Heart Medical Center, Fuzhou, Fujian, P.R. China; Department of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China; Fujian Key Laboratory of Vascular Aging (Fujian Medical University), Fuzhou, Fujian, P.R. China; Fujian Institute of Geriatrics, Fuzhou, Fujian, P.R. China .
Clin Invest Med. 2021 Dec 31;44(4):E23-30. doi: 10.25011/cim.v44i4.37593.
To evaluate the relationship between the serum calcitonin gene-related peptide (CGRP) level and severity of coronary stenosis.
A total of 233 eligible patients who underwent coronary angiography were divided into two groups: a control and a coronary heart disease (CHD) group. The angiographic severity of coronary stenosis was evaluated by SYNTAX and Gensini scores. The incidence of major adverse cardiovascular events within two years was collected.
A negative correlation between serum CGRP levels and Gensini scores was observed in all patients (r=-0.352, p<0.001), the control group (r=-0.422, p<0.001) and the CHD group (r=-0.393, p<0.001). Serum CGRP levels were negatively associated with SYNTAX scores in the CHD group (r=-0.522, p<0.001). The area under the curve of CGRP for identifying high SYNTAX scores (>22) was 0.772 [95% confidence interval (CI): 0.673-0.870, p<0.001], and for identifying high Gensini scores was 0.744 (95% CI: 0.646-0.842, p<0.001). A CGRP concentration of 25.05 pg/ml was selected as the cutoff point. A low CGRP level (<25.05 pg/ml) was an independent predictor of severe coronary stenosis, a SYNTAX score >22 [odds ratio (OR) =5.819, 95% CI: 2.240-15.116; p<0.001] and a high Gensini score (>64) (OR=4.943, 95% CI: 2.020-12.095; p<0.001). The low CGRP group had a higher incidence of major adverse cardiovascular events within two years (11.1 vs. 3.1%, p=0.031).
In coronary atherosclerosis patients without acute myocardial injury, serum CGRP levels were negatively associated with the severity of coronary stenosis.
评估降钙素基因相关肽（CGRP）血清水平与冠状动脉狭窄严重程度之间的关系。
共纳入 233 例接受冠状动脉造影的患者，分为对照组和冠心病（CHD）组。通过 SYNTAX 和 Gensini 评分评估冠状动脉狭窄的严重程度。收集 2 年内主要不良心血管事件的发生率。
所有患者（r=-0.352，p<0.001）、对照组（r=-0.422，p<0.001）和 CHD 组（r=-0.393，p<0.001）血清 CGRP 水平与 Gensini 评分呈负相关。CHD 组血清 CGRP 水平与 SYNTAX 评分呈负相关（r=-0.522，p<0.001）。CGRP 用于识别高 SYNTAX 评分（>22）的曲线下面积为 0.772 [95%置信区间（CI）：0.673-0.870，p<0.001]，用于识别高 Gensini 评分的曲线下面积为 0.744（95%CI：0.646-0.842，p<0.001）。选择 25.05 pg/ml 的 CGRP 浓度作为截断点。低 CGRP 水平（<25.05 pg/ml）是严重冠状动脉狭窄、SYNTAX 评分>22（优势比[OR] =5.819，95%CI：2.240-15.116；p<0.001）和高 Gensini 评分（>64）（OR=4.943，95%CI：2.020-12.095；p<0.001）的独立预测因子。低 CGRP 组在 2 年内发生主要不良心血管事件的发生率较高（11.1%比 3.1%，p=0.031）。
在无急性心肌损伤的冠状动脉粥样硬化患者中，血清 CGRP 水平与冠状动脉狭窄严重程度呈负相关。
