Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Laboratory of Clinical Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Life Sci. 2019 Feb 15;219:329-335. doi: 10.1016/j.lfs.2019.01.021. Epub 2019 Jan 16.
The aim of this study was to evaluate the association between serum soluble semaphorin4D (sSema4D) and coronary heart disease (CHD) and the extent of coronary artery stenosis.
The study included 188 cases that underwent coronary angiography because of precordial pain. One hundred and twenty-eight cases were diagnosed with CHD; 60 cases with negative coronary angiography served as controls. Coronary stenosis was evaluated by the number of diseased coronary artery and Gensini scoring system. Serum sSema4D and C-reactive protein (CRP) levels were measured.
Serum sSema4D levels in CHD patients were significantly higher than those of controls (p < 0.001) and the levels in those with acute coronary syndrome (ACS) were significantly higher than those with stable angina pectoris (p < 0.05) and controls (p < 0.05). Higher levels of serum sSema4D were observed in the group with high Gensini scores. Serum sSema4D concentration was positively correlated with the Gensini score (r = 0.735, p < 0.001) and was the only independent factor that significantly influenced the Gensini score (p < 0.001). Serum sSema4D levels were positively correlated with CRP levels in all subjects (r = 0.182, p = 0.013). Elevated sSema4D and CRP levels were independently associated with the presence of CHD.
Serum sSema4D levels were increased in CHD patients, especially in those with ACS. Serum sSema4D may be an independent risk factor for CHD and reflect the extent of coronary artery stenosis to some extent.
本研究旨在评估血清可溶性信号素 4D（sSema4D）与冠心病（CHD）及冠状动脉狭窄程度的关系。
本研究纳入了 188 例因胸痛而行冠状动脉造影的患者。其中 128 例被诊断为 CHD，60 例冠状动脉造影阴性作为对照组。通过病变冠状动脉数量和 Gensini 评分系统评估冠状动脉狭窄程度。检测血清 sSema4D 和 C 反应蛋白（CRP）水平。
CHD 患者血清 sSema4D 水平明显高于对照组（p<0.001），急性冠脉综合征（ACS）患者血清 sSema4D 水平明显高于稳定型心绞痛患者（p<0.05）和对照组（p<0.05）。Gensini 评分较高的患者血清 sSema4D 水平较高。血清 sSema4D 浓度与 Gensini 评分呈正相关（r=0.735，p<0.001），是显著影响 Gensini 评分的唯一独立因素（p<0.001）。所有受试者中，血清 sSema4D 水平与 CRP 水平呈正相关（r=0.182，p=0.013）。sSema4D 和 CRP 水平升高与 CHD 的存在独立相关。
CHD 患者血清 sSema4D 水平升高，尤其是 ACS 患者。血清 sSema4D 可能是 CHD 的独立危险因素，并在一定程度上反映冠状动脉狭窄程度。
