以色列犹太人中与DR4相关的HLA-Dw簇以及一种新的与DR4相关的Dw亚型的定义：Dw"SHA"

HLA-Dw clusters associated with DR4 in Israeli Jews and the definition of a new DR4 associated Dw subtype: Dw"SHA".

作者信息

Cohen N, Mickelson E, Amar A, Battat S, Hansen J A, Brautbar C

出版信息

Hum Immunol. 1987 Jul;19(3):179-88. doi: 10.1016/0198-8859(87)90068-1.

Abstract

A homozygous typing cell (HTC), that identifies a newly defined HLA-Dw determinant Dw"SHA," is described. The donor of the HTC was a Yeminite Jew and an offspring of first cousin marriage. This cell is not included in the known DR4-associated specificity clusters Dw4,Dw10,Dw13,Dw14,Dw15, or the provisional cluster Dw"KT2." Dw"SHA" was shown to segregate with DR4 positive haplotypes in family analysis, and in a population study was present in three of 43 unrelated DR4 positive individuals. This new Dw determinant was detected in Israeli Jews of Yemenite origin bearing the haplotype HLA-Bw41,DR4,DQw3. This indicates that Bw41,DR4,DQw3,Dw"SHA" may represent a typical allele combination in Yemenite Jews. Among 43 DR4 haplotypes in Israeli Jews, Dw10 had the highest antigen frequency (41.8%), whereas in American Caucasoids and in Japanese, Dw4 and Dw15 were most frequent, 44% and 40.5%, respectively.

摘要

本文描述了一种纯合分型细胞（HTC），它可识别新定义的HLA-Dw决定簇Dw“SHA”。该HTC的供体是一名也门裔犹太人，系近亲结婚的后代。此细胞不包含在已知的与DR4相关的特异性簇Dw4、Dw10、Dw13、Dw14、Dw15或临时簇Dw“KT2”中。在家族分析中，Dw“SHA”显示与DR4阳性单倍型共分离，并且在一项群体研究中，43名无关的DR4阳性个体中有3人携带该决定簇。在携带单倍型HLA-Bw41、DR4、DQw3的也门裔以色列犹太人中检测到了这种新的Dw决定簇。这表明Bw41、DR4、DQw3、Dw“SHA”可能代表也门裔犹太人中的一种典型等位基因组合。在以色列犹太人的43种DR4单倍型中，Dw10的抗原频率最高（41.8%），而在美国白种人和日本人中，Dw4和Dw15最为常见，分别为44%和40.5%。