环丙沙星、氨苄西林和氯霉素治疗实验性流感嗜血杆菌肺炎的疗效比较

Comparative efficacies of ciprofloxacin, ampicillin and chloramphenicol in treatment of experimental Haemophilus influenzae pneumonia.

作者信息

Kemmerich B, Borner K, Pennington J E

出版信息

J Antimicrob Chemother. 1987 Jul;20(1):77-83. doi: 10.1093/jac/20.1.77.

DOI:10.1093/jac/20.1.77

Abstract

An experimental murine model of bacteraemic Haemophilus influenzae pneumonia was used to evaluate the therapeutic efficacy of ciprofloxacin, as compared with ampicillin and chloramphenicol. An ampicillin-sensitive (AS) and an ampicillin-resistant (AR) challenge strain were employed. Ciprofloxacin treatment produced intrapulmonary killing of H. influenzae which was superior to that achieved with ampicillin (P less than 0.001, both strains) and chloramphenicol (P less than 0.001, strain AS; P less than 0.005, strain AR). Likewise, survival from strain AS pneumonia was 61% in the ciprofloxacin-treated animals, as compared with 43% for the chloramphenicol-treated, and 22% for the ampicillin-treated groups. We conclude that ciprofloxacin may be an effective agent in treating pneumonia caused by either ampicillin-sensitive or ampicillin-resistant strains of H. influenzae.

摘要

采用实验性鼠类菌血症性流感嗜血杆菌肺炎模型，与氨苄西林和氯霉素相比，评估环丙沙星的治疗效果。使用了一株氨苄西林敏感（AS）和一株氨苄西林耐药（AR）攻击菌株。环丙沙星治疗可使肺内流感嗜血杆菌被杀灭，其效果优于氨苄西林（两种菌株均P<0.001）和氯霉素（AS菌株P<0.001；AR菌株P<0.005）。同样，环丙沙星治疗组中由AS菌株引起的肺炎的存活率为61%，而氯霉素治疗组为43%，氨苄西林治疗组为22%。我们得出结论，环丙沙星可能是治疗由氨苄西林敏感或耐药流感嗜血杆菌菌株引起的肺炎的有效药物。