Soyata Amelia, Hasanah Aliya Nur, Rusdiana Taofik
Padjadjaran University Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Sumedang, Indonesia.
Padjadjaran University Faculty of Pharmacy, Department of Analysis of Pharmaceutical and Medical Chemistry, Sumedang, Indonesia.
Turk J Pharm Sci. 2021 Dec 31;18(6):799-810. doi: 10.4274/tjps.galenos.2020.79106.
Soybeans [ (L.)] are a good source of isoflavones. The main isoflavone components of soybean are daidzein, genistein, and glycitein. World soybean production is very high. Because of its pharmacological activity, soy isoflavone intake over a long period of time may result in interactions with the drugs. This review summarizes soy isoflavone-drug interactions based on the pharmacokinetic parameters. Soy isoflavones have pharmacokinetic interactions with celecoxib, theophylline, paclitaxel, midazolam, imatinib, carbamazepine, valproic acid, repaglinide, omeprazole and danofloxacin. This is due to the changes in the area under the curve, maximum serum concentration, time that a drug is present at the maximum concentration in serum, clearance and half-life of the drugs when delivered together with soy isoflavones. The mechanisms of pharmacokinetic interactions occurs through the inhibition/induction of drug metabolizing cytochrome P450 (CYP450) enzymes such as CYP3A4, CYP2A1, and CYP2C9 or through the inhibition of drug transporters such as P-glycoprotein and breast cancer resistance protein. Thus, the consumption of soybean, soy isoflavones or soy products with drugs needs to be reconsidered.
大豆[ (L.)]是异黄酮的良好来源。大豆中的主要异黄酮成分是大豆苷元、染料木黄酮和黄豆黄素。世界大豆产量非常高。由于其药理活性，长期摄入大豆异黄酮可能会导致与药物发生相互作用。本综述基于药代动力学参数总结了大豆异黄酮与药物的相互作用。大豆异黄酮与塞来昔布、茶碱、紫杉醇、咪达唑仑、伊马替尼、卡马西平、丙戊酸、瑞格列奈、奥美拉唑和达氟沙星存在药代动力学相互作用。这是因为当与大豆异黄酮一起给药时，药物的曲线下面积、最大血清浓度、药物在血清中达到最大浓度的时间、清除率和半衰期会发生变化。药代动力学相互作用的机制是通过抑制/诱导药物代谢细胞色素P450（CYP450）酶，如CYP3A4、CYP2A1和CYP2C9，或通过抑制药物转运体，如P-糖蛋白和乳腺癌耐药蛋白。因此，需要重新考虑大豆、大豆异黄酮或大豆制品与药物同时食用的情况。
