大鼠肾移植存活中的非主要组织相容性系统免疫遗传影响。
Non-major histocompatibility system immunogenetic influences in rat renal allograft survival.
作者信息
Paris A M, Bishop C, Festenstein H, Gunther E
出版信息
Transplantation. 1978 May;25(5):252-4. doi: 10.1097/00007890-197805000-00006.
Abstract
H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (P less than 0.01) at 105 days. These results can best be explained if non-H-1 and intra-MHS amplifiers and/or suppressors are invoked.
摘要
H-1不相容大鼠肾移植存活率受非主要组织相容性系统（MHS）基因的强烈影响。在四种不同的非MHS背景下进行相同的H-1（MHS）不相容性测试，结果差异很大，在105天时，最佳和最差结果之间的存活率分数从11%到60%不等（P小于0.01）。如果引入非H-1和MHS内的增强子和/或抑制子，这些结果就能得到最好的解释。
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