Wortman J A, Alavi A, Attie M, Yudd A P, Johnston S A, Greenberg J
J Nucl Med. 1987 Sep;28(9):1447-52.
We have utilized a quantitative autoradiographic method as a means of evaluating amino acid uptake of the rat parathyroid gland for the ultimate purpose of finding agents potentially suitable for position emission tomographic scanning of parathyroid glands. L-[1-14C]leucine and L-[guanido-14C]arginine were evaluated because of their relatively high content in the synthetic products of the parathyroid glands compared with other neck tissues, thyroid gland, and muscle. Carbon-14 leucine disappeared rapidly from plasma following intravenous injection and there was relatively selective uptake of the [14C]leucine and [14C]arginine by the parathyroid glands when compared with uptake by the thyroid gland and neck muscle. These data suggest that both agents warrant further investigation for their potential utility in positron emission tomographic scanning of the parathyroid gland.
我们采用了一种定量放射自显影方法来评估大鼠甲状旁腺对氨基酸的摄取，最终目的是寻找可能适用于甲状旁腺正电子发射断层扫描的药物。由于与其他颈部组织、甲状腺和肌肉相比，甲状旁腺合成产物中L-[1-¹⁴C]亮氨酸和L-[胍基-¹⁴C]精氨酸的含量相对较高，因此对它们进行了评估。静脉注射后，¹⁴C-亮氨酸迅速从血浆中消失，与甲状腺和颈部肌肉摄取相比，甲状旁腺对[¹⁴C]亮氨酸和[¹⁴C]精氨酸有相对选择性摄取。这些数据表明，这两种药物在甲状旁腺正电子发射断层扫描中的潜在效用都值得进一步研究。
