淋巴细胞亚群水平升高可准确预测BB大鼠的糖尿病状态。

Elevated levels of a lymphocyte subset accurately predict the diabetic state in the BB rat.

作者信息

Francfort J W, Naji A, Silvers W K, Barker C F

出版信息

Pancreas. 1987;2(2):141-5. doi: 10.1097/00006676-198703000-00003.

DOI:10.1097/00006676-198703000-00003

Abstract

The frequency of Ia antigen bearing W3/13 positive lymphocytes from the blood of 68 bio-breeding (BB) diabetes-prone rats was analyzed with monoclonal antibodies to determine whether elevated levels of these cells could predict which animals would subsequently become hyperglycemic. Selecting a value of greater than or equal to 4.00% as elevated, the sensitivity of this assay in predicting diabetes was 85%, while the specificity was 83%. We believe that elevated levels of Ia antigen bearing W3/13 positive lymphocytes reflect an ongoing immune process and accurately predict the likelihood of developing spontaneous hyperglycemia when obtained from a high risk population.

摘要

用单克隆抗体分析了68只生物繁殖（BB）糖尿病易患大鼠血液中携带Ia抗原的W3/13阳性淋巴细胞的频率，以确定这些细胞水平的升高是否能够预测哪些动物随后会出现高血糖。选择大于或等于4.00%的值作为升高水平，该检测预测糖尿病的敏感性为85%，特异性为83%。我们认为，携带Ia抗原的W3/13阳性淋巴细胞水平的升高反映了一个正在进行的免疫过程，并且当从高危群体中获取时，能够准确预测发生自发性高血糖的可能性。