Kao G W, Peyman G A, Fiscella R, House B
Retina. 1987 Summer;7(2):80-3. doi: 10.1097/00006982-198700720-00004.
The authors investigated the retinal toxicity of the antiviral agent ganciclovir after its addition to vitrectomy infusion fluid in rabbit eyes. Intravitreal infusion of the drug in concentrations up to 30 micrograms/ml produced no electroretinographic or histologic changes suggestive of retinal toxicity. Ganciclovir in vitrectomy infusion fluid has potential therapeutic benefit in viral retinitis (particularly in cytomegalovirus retinitis) associated with vitreous traction or rhegmatogenous retinal detachment. Based on the median inhibitory doses of ganciclovir against various herpes group viruses and the results of this study, a concentration of 30 micrograms/ml or less of the drug is recommended for vitrectomy infusion solution.
作者研究了抗病毒药物更昔洛韦添加到兔眼玻璃体切割术灌注液后对视网膜的毒性。向玻璃体内注入浓度高达30微克/毫升的该药物，未产生提示视网膜毒性的视网膜电图或组织学变化。玻璃体切割术灌注液中的更昔洛韦对与玻璃体牵引或孔源性视网膜脱离相关的病毒性视网膜炎（特别是巨细胞病毒性视网膜炎）具有潜在治疗益处。根据更昔洛韦对各种疱疹病毒组的半数抑制剂量以及本研究结果，建议玻璃体切割术灌注溶液中该药物浓度为30微克/毫升或更低。
