玻璃体内注射乙基脱氧尿苷和锌的视网膜毒性

Retinal toxicity of intravitreal ethyldeoxyuridine and zinc.

作者信息

Nikoleit J R, Peyman G A, Lagouros P, Fiscella R

机构信息

Department of Ophthalmology, University of Illinois College of Medicine, Chicago.

出版信息

Ann Ophthalmol. 1988 Oct;20(10):385-7.

PMID:3207311

Abstract

We investigated the toxicity of intravitreal zinc sulfate, zinc gluconate, and ethyldeoxyuridine (EDU) in albino rabbits. Various concentrations of EDU were added to the infusion solution during pars plana vitrectomy. Retinal changes were observed by light microscopy after intravitreal injections containing 20 micrograms of zinc gluconate, all concentrations of zinc sulfate, and 400 micrograms of EDU. No histologic or electroretinographic alterations occurred with doses of 15 micrograms or less of zinc gluconate or 200 micrograms or less of EDU. When added to the vitrectomy solution, concentrations of 20 micrograms/mL or less of EDU appeared nontoxic to the rabbit retina.

摘要

我们研究了玻璃体内注射硫酸锌、葡萄糖酸锌和乙脱氧尿苷（EDU）对白化兔的毒性。在扁平部玻璃体切除术中，将不同浓度的EDU添加到灌注液中。在玻璃体内注射含20微克葡萄糖酸锌、所有浓度的硫酸锌以及400微克EDU后，通过光学显微镜观察视网膜变化。葡萄糖酸锌剂量为15微克或更低、EDU剂量为200微克或更低时，未出现组织学或视网膜电图改变。当添加到玻璃体切除溶液中时，EDU浓度为20微克/毫升或更低时对兔视网膜似乎无毒。