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[丙泊酚与恩氟烷用于颈椎手术的麻醉及苏醒比较研究]

[Comparative study of anesthesia and recovery with propofol and enflurane in cervical surgery].

作者信息

Gindre B, Baulieux D, Paturel B, Ray M, Boulétreau P

出版信息

Ann Fr Anesth Reanim. 1987;6(4):277-9. doi: 10.1016/s0750-7658(87)80039-4.

Abstract

The recovery times and the state of postoperative awakening were studied after anaesthesia with propofol or enflurane. The forty patients who were to undergo surgery for cold thyroid nodules were divided into two homogeneous groups which were similar in age, sex, weight and length of surgery. In one group, induction was carried out with propofol, fentanyl, pancuronium bromide, and maintained with 9 mg X kg-1 X h-1 propofol. In the other group, this was done with thiopentone, fentanyl, pancuronium bromide, followed by 0.8% enflurane. Repeat injections of fentanyl were given as required. The time between stopping giving the anaesthetic drug and eye opening was measured, as well as the performance in memorizing and sorting numbers; these two tests were carried out before and 2 h after surgery. The overall results did not show any differences between the two groups in recovery time or quality of awakening. In the propofol group, recovery time and quality were better than in the enflurane group if the patient was less than 50 years old or surgery lasted less than 100 min. In the propofol group, there were significant correlations between recovery time and age (r = 0.83), and between recovery time and duration of surgery (r = 0.87). The doses of this new product should therefore be modified according to the age of the patient and the length of surgery.

摘要

研究了丙泊酚或恩氟烷麻醉后的恢复时间和术后苏醒状态。将40例拟行甲状腺冷结节手术的患者分为两组,两组在年龄、性别、体重和手术时长方面相似。一组采用丙泊酚、芬太尼、潘库溴铵诱导麻醉,并用9mg·kg⁻¹·h⁻¹的丙泊酚维持麻醉。另一组采用硫喷妥钠、芬太尼、潘库溴铵诱导麻醉,随后用0.8%的恩氟烷维持麻醉。根据需要重复注射芬太尼。测量停止给予麻醉药物至睁眼的时间,以及记忆和分类数字的表现;这两项测试在手术前和手术后2小时进行。总体结果显示,两组在恢复时间或苏醒质量方面没有差异。在丙泊酚组中,如果患者年龄小于50岁或手术持续时间小于100分钟,恢复时间和质量优于恩氟烷组。在丙泊酚组中,恢复时间与年龄之间存在显著相关性(r = 0.83),恢复时间与手术时长之间也存在显著相关性(r = 0.87)。因此,应根据患者年龄和手术时长调整这种新产品的剂量。

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