Millar J M, Jewkes C F
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford.
Anaesthesia. 1988 Sep;43(9):738-43. doi: 10.1111/j.1365-2044.1988.tb05743.x.
The anaesthetic conditions, recovery and side effects for 48 hours postoperatively were compared after anaesthesia for day surgery using propofol or thiopentone-enflurane with and without alfentanil. Propofol provided good conditions for surgery with faster immediate recovery (p less than 0.001); patients who received it were fit for discharge significantly sooner (p less than 0.001). Visual analogue scores of postoperative wellbeing showed an improvement in both propofol groups (p less than 0.01); after thiopentone and enflurane the scores were reduced and took 2 days to return to the pre-operative values. There was a significant (p less than 0.001) reduction in postoperative morbidity in both the groups that received propofol up to 24 hours after discharge. The addition of alfentanil improved anaesthetic conditions and reduced postoperative morbidity with both propofol and thiopentone-enflurane.
比较了使用丙泊酚或硫喷妥钠 - 恩氟烷并加或不加阿芬太尼进行日间手术麻醉后48小时的麻醉条件、恢复情况及副作用。丙泊酚为手术提供了良好条件,即时恢复更快(p小于0.001);接受丙泊酚麻醉的患者出院明显更早(p小于0.001)。术后舒适度的视觉模拟评分显示,两个丙泊酚组均有改善(p小于0.01);硫喷妥钠和恩氟烷麻醉后评分降低,需2天才能恢复到术前值。在出院后长达24小时内,接受丙泊酚的两组患者术后发病率均显著降低(p小于0.001)。阿芬太尼的加入改善了丙泊酚和硫喷妥钠 - 恩氟烷的麻醉条件,并降低了术后发病率。