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衰老对人类E玫瑰花结形成细胞、自发细胞介导的细胞毒性及抗体依赖性细胞毒性的影响。

Aging influence on the E-rosette forming cells, spontaneous cell mediated cytotoxicity, and antibody dependent cellular cytotoxicity in humans.

作者信息

Olinescu A, Hristescu S, Poliopol M, Vasiliu E, Saragea M, Saragea A, Perieteanu R

出版信息

Arch Immunol Ther Exp (Warsz). 1987;35(1):1-10.

PMID:3498459
Abstract

In 131 adults and 107 aging healthy subjects of both sexes, the percentage of the T lymphocytes in peripheral blood and the cytotoxic activities of NK and K cells, were determined. No age-related differences have been found in the number of peripheral blood lymphocytes, the binding of NK cells to the K562 targets, the percentage of E rosette forming cells and the ADCC level. An increased proportion of T suppressor lymphocytes in elderly subjects and a large inter- and intra-individual variation of NK cells activity in both adult and aged subjects were found.

摘要

在131名成年人和107名健康老年受试者(男女均有)中,测定了外周血中T淋巴细胞的百分比以及NK细胞和K细胞的细胞毒性活性。在外周血淋巴细胞数量、NK细胞与K562靶标的结合、E花环形成细胞的百分比以及ADCC水平方面,未发现与年龄相关的差异。发现老年受试者中T抑制淋巴细胞的比例增加,并且在成年和老年受试者中NK细胞活性均存在较大的个体间和个体内差异。

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Arch Immunol Ther Exp (Warsz). 1987;35(1):1-10.
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