Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.
Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.
Int Ophthalmol. 2022 May;42(5):1381-1389. doi: 10.1007/s10792-021-02126-z. Epub 2022 Jan 5.
To investigate the three-dimensional topographic changes of anterior chamber depth (ACD) following cataract surgery.
Seventy-eight eyes with age-related cataract undergoing phacoemulsification and intraocular lens (IOL) implantation were retrospectively enrolled. Participants were evaluated with Pentacam for ACD topography before and approximately four weeks after the surgery. The absolute changes of ACD (AACD) and the relative changes of ACD (RACD) topography were calculated, and three-dimensional topographic contours were plotted. The influence of age, gender, distance to corneal apex (DCA), temporal-nasal and superior-inferior on AACD and RACD was analyzed.
Both AACD and RACD were negatively correlated with the DCA (p < 0.001; p < 0.001) and positively correlated with the age at all DCA (p < 0.05 for all the analyses). Significantly greater AACD and RACD were observed in female subjects (p < 0.05, respectively, at all DCA). AACD was significantly larger in the temporal compared with the nasal region (p < 0.001) and at the superior compared with the inferior region (p < 0.001), but not RACD. Subgroup analysis indicated that the significant difference of the AACD between the temporal and nasal regions was manifested at the DCA of more than 6 mm (p < 0.001), and the difference between the superior and inferior regions was observed at 2 mm DCA for both AACD (p < 0.001) and RACD (p = 0.001).
We depicted the topographic changes of ACD following cataract surgery and found that it was significantly influenced by age, gender, DCA and quadrant location. The research provided the basis for including postoperative ACD topography prediction before cataract surgery in the future.
研究白内障术后前房深度（ACD）的三维地形变化。
回顾性纳入 78 例年龄相关性白内障行超声乳化白内障吸除术及人工晶状体（IOL）植入术的患者。使用 Pentacam 对术前及术后约 4 周时的 ACD 地形进行评估。计算 ACD 的绝对变化量（AACD）和相对变化量（RACD），绘制三维地形轮廓。分析年龄、性别、至角膜顶点距离（DCA）、颞侧-鼻侧和上侧-下侧对 AACD 和 RACD 的影响。
AACD 和 RACD 均与 DCA 呈负相关（p<0.001;p<0.001），与年龄呈正相关（所有分析均 p<0.05）。女性患者的 AACD 和 RACD 显著更大（p<0.05，所有 DCA 均如此）。ACD 在颞侧大于鼻侧（p<0.001），在上侧大于下侧（p<0.001），但 RACD 无差异。亚组分析表明，颞侧与鼻侧之间 AACD 的显著差异仅在 DCA 大于 6mm 时表现出来（p<0.001），上侧与下侧之间的差异在 DCA 为 2mm 时即可观察到，对于 AACD（p<0.001）和 RACD（p=0.001）均如此。
我们描绘了白内障术后 ACD 的地形变化，发现其显著受年龄、性别、DCA 和象限位置的影响。该研究为今后在白内障术前纳入术后 ACD 地形预测提供了依据。
