First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
J Cardiovasc Transl Res. 2022 Aug;15(4):730-739. doi: 10.1007/s12265-021-10204-x. Epub 2022 Jan 4.
Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet-associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases. Cardiovascular diseases, especially ischemic heart disease (IHD), have always been the focus of attention because of their high morbidity and mortality. Atherosclerosis and myocardial remodeling are two important pathologic processes of IHD, and LDs and other organelles are involved in the development of the disease. The interaction between LDs and ER is involved in the formation of foam cells in atherosclerosis. And LDs, mitochondria, and lysosomes also affect the remodeling of cardiomyocytes by affecting ROS production and regulating PI3K/AKT pathways. In this article, we will review the role of LDs in IHD.
脂滴（LD）是一种亚细胞细胞器，起源于内质网（ER）。LD 可以在细胞器之间灵活移动，并在细胞内储存能量。近年来，LD 和与脂滴相关的蛋白质在国内外受到了更多的关注，特别是在心血管疾病方面。心血管疾病，特别是缺血性心脏病（IHD），由于其高发病率和死亡率，一直是关注的焦点。动脉粥样硬化和心肌重构是 IHD 的两个重要病理过程，而 LD 及其他细胞器参与了疾病的发生发展。LD 与 ER 的相互作用参与了动脉粥样硬化中泡沫细胞的形成。而 LD、线粒体和溶酶体也通过影响 ROS 产生和调节 PI3K/AKT 通路来影响心肌细胞的重构。本文将综述 LD 在 IHD 中的作用。
