Faculty of Medicine, Dept. of Anatomy and HiLIFE, Univ. of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Curr Opin Cell Biol. 2019 Apr;57:64-70. doi: 10.1016/j.ceb.2018.11.002. Epub 2018 Nov 23.
The formation of neutral lipid filled and phospholipid monolayer engulfed lipid droplets (LDs) from the bilayer of the endoplasmic reticulum (ER) is an active area of investigation. This process harnesses the biophysical properties of the lipids involved and necessitates cooperation of protein machineries in both organelle membranes. Increasing evidence suggests that once formed, LDs keep close contact to the mother organelle and that this may be achieved via several, morphologically distinct and potentially functionally specialized connections. These may help LDs to dynamically respond to changes in lipid metabolic status sensed by the ER. In this review, we will discuss recent progress in understanding how LDs interact with the ER.
中性脂质填充和磷脂单层吞噬内质网 (ER) 双层中的脂质滴 (LD) 的形成是一个活跃的研究领域。这个过程利用了涉及的脂质的物理特性，并需要细胞器膜中蛋白质机器的合作。越来越多的证据表明，一旦形成，LDs 就会与母细胞器保持密切接触，这可以通过几种形态不同且可能具有功能特异性的连接来实现。这些连接可能有助于 LD 对 ER 感知到的脂质代谢状态变化做出动态响应。在这篇综述中，我们将讨论关于 LD 与 ER 相互作用的最新进展。
