Monk C R, Coates D P, Prys-Roberts C, Turtle M J, Spelina K
Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Infirmary.
Br J Anaesth. 1987 Aug;59(8):954-60. doi: 10.1093/bja/59.8.954.
The haemodynamic effects of propofol at two infusion rates (54-65 and 108-130 micrograms kg-1 min-1) have been studied during peripheral arterial surgery in eight elderly patients premedicated with morphine sulphate 0.15 mg kg-1. The haemodynamic response to laryngoscopy and intubation was partially suppressed: neither arterial pressure nor heart rate exceeded awake values. During stable anaesthesia at the lower infusion rate before surgery, systolic (SAP) and diastolic (DAP) arterial pressures were significantly decreased from awake values (SAP: -47%; DAP: -46%) as a result of decreases in cardiac output (-32%) and systemic vascular resistance (SVR) (-9%). During surgery, with either spontaneous (SV) or intermittent positive pressure (IPPV) ventilation, both infusion rates were associated with decreases in arterial pressures when compared with the awake state. Cardiac output was decreased (SV: -35%, IPPV: -36%) and SVR increased (SV: +22%, IPPV: +45%) at the lower infusion rate; similar changes were observed during the faster infusion rate.
在8例用0.15mg/kg硫酸吗啡进行术前用药的老年患者行外周动脉手术期间，研究了两种输注速率（54 - 65和108 - 130微克/千克/分钟）丙泊酚的血流动力学效应。喉镜检查和插管时的血流动力学反应被部分抑制：动脉压和心率均未超过清醒时的值。在术前较低输注速率的稳定麻醉期间，由于心输出量降低（-32%）和全身血管阻力降低（-9%），收缩压（SAP）和舒张压（DAP）较清醒时显著降低（SAP：-47%；DAP：-46%）。手术期间，无论是自主呼吸（SV）还是间歇正压通气（IPPV），与清醒状态相比，两种输注速率均与动脉压降低有关。较低输注速率下心输出量降低（SV：-35%，IPPV：-36%），全身血管阻力增加（SV：+22%，IPPV：+45%）；较快输注速率期间观察到类似变化。
