Prys-Roberts C, Sear J W, Low J M, Phillips K C, Dagnino J
Anesth Analg. 1983 Mar;62(3):317-23. doi: 10.1213/00000539-198303000-00005.
The hemodynamic effects of methohexital, at infusion rates of 60-65 and 120 micrograms/kg/min with concomitant inhalation of 67% nitrous oxide in oxygen, have been studied during spontaneous and controlled ventilation in 8 patients. Under most of the conditions studied methohexital infusion anesthesia was associated with lower arterial pressure (-13% to -33%) than in the awake state, decreased cardiac output (-26% to -38%), and increased systemic vascular resistance (+5% to +37%) during surgery, but also with decreased cardiac output (-25%) and decreased systemic vascular resistance (-13%) during anesthesia without surgery. The higher infusion rate was not associated with decreases in arterial pressure or cardiac output during either spontaneous or controlled ventilation. The hemodynamic response to laryngoscopy and intubation was poorly suppressed by methohexital in that peak arterial pressures exceeded the preanesthetic values by 33%. No evidence of impaired hepatocellular function was found after infusions of methohexital lasting up to 4 h.
在8例患者的自主通气和控制通气过程中，研究了美索比妥以60 - 65微克/千克/分钟和120微克/千克/分钟的输注速率，并同时吸入67%氧化亚氮和氧气时的血流动力学效应。在大多数研究条件下，美索比妥输注麻醉与手术期间动脉压低于清醒状态（-13%至-33%）、心输出量降低（-26%至-38%）以及全身血管阻力增加（+5%至+37%）相关，但在非手术麻醉期间也伴有心输出量降低（-25%）和全身血管阻力降低（-13%）。无论是自主通气还是控制通气，较高的输注速率均未导致动脉压或心输出量降低。美索比妥对喉镜检查和插管的血流动力学反应抑制不佳，因为动脉压峰值超过麻醉前值33%。输注美索比妥长达4小时后，未发现肝细胞功能受损的证据。
