无氧化剂促进的 C(sp3)-H 酰氧基化吲哚啉-3-酮的阳极交叉脱氢 C(sp)-O 偶联反应。
Anodic C(sp)-H Acyloxylation of Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp)-O Coupling.
机构信息
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China.
出版信息
J Org Chem. 2022 Jan 21;87(2):1335-1347. doi: 10.1021/acs.joc.1c02644. Epub 2022 Jan 5.
An efficient anodic C(sp)-H acyloxylation protocol has been established via intermolecular cross-dehydrogenative C(sp)-O coupling. The protocol provides various C2-acyloxy indolin-3-ones without the addition of metal catalysts and external oxidants because indolin-3-ones can be directly oxidized at the anode. The effective application of several medical drugs and the realization of the gram-scale experiment have proven the practicality of this protocol.
建立了一种通过分子间交叉脱氢 C(sp)-O 偶联的高效阳极 C(sp)-H 酰氧基化的方法。该方法无需添加金属催化剂和外部氧化剂，因为阳极可以直接氧化吲哚啉-3-酮，因此可以得到各种 C2-酰氧基吲哚啉-3-酮。该方法的实际应用已经证明了其可行性，包括几种药物的有效应用和克级实验的实现。
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