1Institute for Medical Research and Occupational Health, Croatian Poison Control Centre, Zagreb, Croatia.
2Children's Hospital Zagreb, Department for Paediatric Clinical Pharmacology and Toxicology, Zagreb, Croatia.
Arh Hig Rada Toksikol. 2021 Dec 30;72(4):299-304. doi: 10.2478/aiht-2021-72-3596.
We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0-5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children's Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.
我们通过分析克罗地亚中毒控制中心（CPCC）的电话咨询记录和萨格勒布儿童医院（CHZ）的治疗案例，描述了 2009 年至 2019 年期间 0-5 岁儿童意外摄入非甾体抗炎药和非阿片类镇痛药的情况。在总共 466 例已确定的病例（411 例来自 CPCC 记录，55 例来自 CHS 医院记录）中，最常摄入的药物为布洛芬（47%）、对乙酰氨基酚（20%）、酮洛芬（15%）和双氯芬酸（11%）。在 94%的情况下，无人监管的儿童摄入了放在他们触手可及范围内的药物。其余 6%是父母或照顾者的用药错误，且通常涉及液体制剂。我们的研究结果可以作为现实生活中的例子，为预防措施提供信息。
