Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA; Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA.
Institute of Clinical Physiology, National Research Council-CNR, Pisa 56100, Italy.
Cell Metab. 2022 Jan 4;34(1):11-20. doi: 10.1016/j.cmet.2021.12.012.
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
体内脂肪过多会导致 2 型糖尿病，而 2 型糖尿病的风险会随着体重指数的增加呈线性增加。因此，全球肥胖症的流行率增加导致 2 型糖尿病的流行率也相应增加。肥胖症和 2 型糖尿病之间联系的细胞和生理机制非常复杂，涉及肥胖引起的β细胞功能、脂肪组织生物学和多器官胰岛素抵抗的改变，这些改变通常可以通过适当的减肥得到改善，甚至可以恢复正常。
