Langley J G, Goldsmid J M, Davies N
Department of Pathology, University of Tasmania Clinical School, Hobart.
Genitourin Med. 1987 Aug;63(4):264-7. doi: 10.1136/sti.63.4.264.
It has been suggested that high zinc concentrations found in men may prevent Trichomonas vaginalis from being established in the male reproductive tract. In this investigation T vaginalis was readily killed at concentrations of zinc that occur in the prostatic fluid of healthy men (minimum trichomonacidal concentration (MTC) of 6.4 mmol/l). T vaginalis was also shown to be killed by human prostatic extracts as well as by human seminal fluid, even when the zinc content was much lower than the MTC for T vaginalis. It seems likely, therefore, that there are at least two antitrichomonal mechanisms in the male reproductive tract, one being zinc dependent and the other not relating to zinc content. Tritrichomonas foetus, which causes venereal trichomoniasis in cattle, was unaffected by bovine seminal fluid and was killed by zinc only at concentrations far higher than those found in the prostatic fluid in the bull (MTC 200 mmol/l).
有人提出,男性体内发现的高锌浓度可能会阻止阴道毛滴虫在男性生殖道中定植。在这项研究中,在健康男性前列腺液中存在的锌浓度下(最低杀滴虫浓度(MTC)为6.4 mmol/l),阴道毛滴虫很容易被杀死。即使当锌含量远低于阴道毛滴虫的MTC时,阴道毛滴虫也被证明会被人类前列腺提取物以及人类精液杀死。因此,男性生殖道中似乎至少存在两种抗滴虫机制,一种依赖锌,另一种与锌含量无关。引起牛性病性毛滴虫病的胎儿三毛滴虫不受牛精液影响,只有在浓度远高于公牛前列腺液中发现的浓度时(MTC为200 mmol/l)才会被锌杀死。