Department of Pathology, Faculty of Medicine, Mansoura University, El-Gomhoria St., Mansoura, Dakahlia, Egypt.
Diagn Pathol. 2022 Jan 5;17(1):1. doi: 10.1186/s13000-021-01174-4.
Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate reductase large subunits (RRM1) and two Ribonucleoside-diphosphate reductase small subunits (RRM2). RRM2 is the building subunit of RNR that is important for synthesis of Deoxynucleoside triphosphate (dNTP) during S phase of cell cycle during DNA replication. RRM2 is associated with poor prognosis in lung and colorectal cancer. In breast cancer, increased RRM2 protein level is strongly correlated with large tumour size, positive lymph node and relapse. In this study, we aimed to study expression of RRM2 in breast cancer and to correlate it with different clinicopathological parameters in Egyptian women.
This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using immunohistochemistry and tissue microarrays.
About 77% of cases were RRM2 positive. High Ki67 was observed in cases with high RRM2 score. The majority of non-luminal cases expressed RRM2, however this was statistically insignificant. In ER positive group, RRM2 expression was associated with shorter disease free survival with borderline significance.
RRM2 protein expression can help in evaluating outcome of breast cancer patients and could be a potential therapeutic target.
乳腺癌是最常见的癌症类型之一。核 苷 酸 还 原 酶 (RNR) 是由两个核糖核苷酸二磷酸还原酶大亚基 (RRM1) 和两个核糖核苷酸二磷酸还原酶小亚基 (RRM2) 组成的异源二聚体四聚体。RRM2 是 RNR 的构建亚基，对于细胞周期 S 期 DNA 复制过程中脱氧核苷三磷酸 (dNTP) 的合成至关重要。RRM2 与肺癌和结直肠癌的不良预后相关。在乳腺癌中，RRM2 蛋白水平的增加与大肿瘤大小、阳性淋巴结和复发强烈相关。在这项研究中，我们旨在研究 RRM2 在乳腺癌中的表达，并将其与埃及女性不同的临床病理参数相关联。
本研究通过免疫组织化学和组织微阵列检测乳腺癌中 RRM2 蛋白的表达，并将结果与其他临床病理变量相关联。
约 77%的病例为 RRM2 阳性。高 Ki67 见于 RRM2 评分高的病例。大多数非腔型病例表达 RRM2，但这无统计学意义。在 ER 阳性组中，RRM2 表达与无病生存期较短相关，具有边缘显著性。
RRM2 蛋白表达有助于评估乳腺癌患者的预后，可能是一个潜在的治疗靶点。
