Bioinformatics analysis revealing prognostic significance of gene in breast cancer.

Ribonucleotide reductase M2 subunit () plays vital roles in many cellular processes such as cell proliferation, invasiveness, migration, angiogenesis, senescence, and tumorigenesis. However, the prognostic significance of gene in breast cancer remains to be investigated. expression was initially evaluated using the Oncomine database. The relevance between level and clinical parameters as well as survival data in breast cancer was analyzed using the Kaplan-Meier Plotter, PrognoScan, and Breast Cancer Gene-Expression Miner (bc-GenExMiner) databases. was overexpressed in different subtypes of breast cancer patients. Estrogen receptor (ER) and progesterone receptor (PR) were negatively correlated with expression. Conversely, the Scarff-Bloom-Richardson (SBR) grade, Nottingham prognostic index (NPI), human epidermal growth factor receptor-2 (HER-2) status, nodal status, basal-like status, and triple-negative status were positively related to level in breast cancer samples with respect to normal tissues. Patients with increased showed worse overall survival, relapse-free survival, distant metastasis-free survival, disease-specific survival, and disease-free survival. also exerted positive effect on metastatic relapse event. Besides, a positive correlation between and genes was confirmed. Bioinformatics analysis revealed that might be used as a predictive biomarker for prognosis of breast cancer. Further studies are needed to more precisely elucidate the value of in evaluating breast cancer prognosis.